4 Best Restaurants in Hilton Head and the Low Country, South Carolina

Michael Anthony's Cucina Italiana

$$$$ | South End Fodor's choice

This restaurant has a convivial spirit, and its innovative pairings and plate presentations are au courant. Expect fresh, top-quality ingredients, simple yet elegant sauces, and waiters who know and care about the food and wine they serve.

37 New Orleans Rd., Hilton Head Island, South Carolina, 29928, USA
843-785–6272
Known For
  • cooking demonstrations
  • on-site market with fresh pasta
  • wine tastings
Restaurants Details
Rate Includes: Closed Sun. and Mon. No lunch, Credit cards accepted, Reservations essential

Red Fish

$$$$ | South End Fodor's choice

Appealing to locals and tourists alike, the menu at upscale Red Fish features classic seafood dishes, mouthwatering apps, and delicious desserts. The contemporary restaurant's wine cellar is filled with some 1,000 bottles, and there's also a retail wineshop as well as indoor and outdoor seating.

Saltus River Grill

$$$$ | Downtown Historic District

This upscale restaurant wins over diners with its sailing motifs, great cocktails, and modern Southern menu. Take in the sunset and a plate of seared sea scallops from the gorgeous outdoor seating area overlooking the waterfront park. From Lowcountry flavors to innovative dishes, Saltus sets the standard for a memorable dining experience.

802 Bay St., Beaufort, South Carolina, 29902, USA
843-379–3474
Known For
  • signature crab bisque
  • raw bar with a tempting array of oysters and sushi
  • thoughtful wine list
Restaurants Details
Rate Includes: No lunch, Reservations essential

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WiseGuys

$$$$ | North End

The red-and-black decor is modern and sophisticated at this lively restaurant on the north end of the island. The food is a spin on the classics, from seafood to steak, and the shared plate menu is on point. A great selection of cocktails and wine makes WiseGuys a popular spot to grab a drink.

1513 Main St., Hilton Head Island, South Carolina, 29926, USA
843-842–8866
Known For
  • a delightful crème brûlée flight and deep-fried bread pudding
  • extensive wine list and cocktail menu
  • charred rib-eye steak entrée
Restaurants Details
Rate Includes: No lunch